AC Milan head coach Stefano Pioli has made multiple changes to the starting line-up that will face Chelsea compared to the team that beat Empoli amid an injury crisis.
Another wave of injuries has hit Milan as Mike Maignan, Davide Calabria, Alessandro Florenzi, Simon Kjaer and Theo Hernandez are all out, plus Alexis Saelemaekers, Junior Messias and Zlatan Ibrahimovic.
Some changes and choices have therefore been forced, with Pioli electing to field Ciprian Tatarusanu in goal with a back four of Sergino Dest, Pierre Kalulu, Fikayo Tomori and Fode Ballo-Toure ahead.
Sandro Tonali and Ismael Bennacer will be in the double pivot, with the attack consisting of Rade Krunic wide on the right, Rafael Leao on the left and Charles De Ketelaere as the playmaker behind Olivier Giroud.
Official Milan XI (4-2-3-1): Tatarusanu; Dest, Kalulu, Tomori, Ballo-Toure; Tonali, Bennacer; Krunic, De Ketelaere, Leao; Giroud.
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Bench: Mirante, Jungdal, Diaz, Rebic, Origi, Pobega, Gabbia, Gala, Coubis
Official Chelsea XI (3-5-2): Kepa; Fofana, Thiago Silva, Koulibaly; James, Loftus-Cheek, Kovacic, Mount, Chilwell; Sterling, Aubameyang
Bench: Bettinelli, Mendy, Jorginho, Pulisic, Chalobah, Broja, Zakaria, Ziyech, Gallagher, Azpilicueta, Havertz, Cucurella.